A Desktop Layout is the way you organize your Orbit GIS windows on your screen: position, size, which windows are open or closed.
You can manually load and save your favorite Desktop Layouts on disc using the Edit menu :
Save and Load your Desktop Layouts in a file. These files have an *.odp extension.
If a workspace has a sibling file with a .odp extension, the Desktop Layouts in the sibling file are automatically loaded and applied as part of the workspace.
You can have your Desktop Layout automatically saved when saving a workspace. To do so, enable the option in the Workspace tab of the Preferences window.
Orbit GIS automatically saves your current Desktop Layout when closing. When restarting, your last layout is recovered.